Analytical Equipment, Laboratory Equipment, Solutions for Industry

Revolutionary droplet microfluidics technology sets the new standard for research

Atrandi-Biosciences-partner-inospectra

Inospectra has become the official partner and representative of the Lithuanian start-up Atrandi Biosciences in the Baltic States. The biotechnology company designs and develops innovative instruments, reagents, and software, enabling scientific and industrial professionals to analyze complex biological samples at single-cell or molecule resolution more efficiently.

“We are very proud to represent the innovative technologies developed by the Atrandi team, which open new application possibilities in scientific and industrial fields. We look forward to offering our customers in Lithuania, Latvia and Estonia top-level droplet microfluidics and Semi-Permeable Capsules (SPCs) technological equipment, which will stimulate and contribute to new discoveries.” , – says Dainius Vasiliauskas, director of Inospectra.

The technologies developed by the Atrandi team provide unprecedented opportunities for high-throughput sample preparation and analysis in sequencing, artificial intelligence and personalized medicine.

Droplet microfluidics

Droplet microfluidics technology is based on breaking the reaction into picoliter and nanoliter droplets. Individual cells or molecules can be isolated in such droplets for further analysis. Thousands of droplets can be generated in one second, enabling high-throughput analysis of biological samples.

Droplet microfluidics technology has already gained momentum in biological, biomedical, and biotechnological sciences and accelerates scientific research because it allows for the highest resolution of a single cell or molecule.

Many laboratories worldwide choose this technology because of its flexibility—any molecular test can be performed using any reagent. Cost-effectiveness—low volumes significantly reduce reagent costs. Sensitivity—high local concentration increases detection efficiency. Speed—high-throughput screening accelerates data collection. In addition, millions of cells or molecules can be analyzed in a few hours, and the precise size of each droplet results in reliable and reproducible results.

Droplet microfluidics technology can be applied in research involving reagent addition steps, single-cell sequencing, antibody discovery, microbial analysis, new drug development, and synthetic microenvironment control.

Semi-Permeable Capsules (SPCs)

Semi-permeable capsules (SPCs) are an advanced technology revolutionizing microfluidics-based multi-step workflows. SPCs are composed of an aqueous core surrounded by a hydrogel shell. The envelope acts as a selective membrane, allowing the free exchange of a minor reaction component while maintaining the breakdown of individual cells or biomolecules.

Semipermeable capsules are made of biocompatible polymer. They can be frozen, thawed, centrifuged, and used with many chemical solutions. Subsequent reactions of millions of semipermeable capsules can be performed in bulk, as can high-throughput screening molecular analysis.

Many laboratories worldwide choose this technology because it allows for multi-step single-cell studies, increasing their fragmentation and optimizing each reaction in the workflow. In addition, this technology is not only easily compatible with various types of cells and biochemical reactions. It provides excellent conditions for optimal cell growth, allowing easy addition of nutrients and removal of waste, releasing intact nucleic acids or living cells, and high throughput in problem sampling studies using mass survey methods.

Semipermeable capsule technology can be applied to microbial DNA sequencing and liquid culture colony studies.

Areas of application

Digital Analysis

Advanced imaging allows droplets to be counted and sorted according to size, shape, or content. Fluorescence-labelled target droplets of molecules and cells can be monitored and analyzed in real-time. This method allows the detection of rare cells and molecules generally invisible in traditional mass analysis.

Droplet Barcoding

Labelling individual droplets with unique oligonucleotides enables high-throughput screening analysis of large populations of cells or molecules. This method allows the simultaneous analysis of tens of thousands of droplets in one experiment and provides a detailed picture of biological processes or molecular interactions.

Custom Workflows

Droplet microfluidics technology enables innovative research and new insights into individual biological systems. Droplet generation, manipulation and analysis can be optimized in selected workflows to increase operational efficiency and sample sensitivity while reducing the cost and time required for experiments.

Atrandi Biosciences solutions

Flux is an easy-to-use microfluidic device that empowers the high-throughput analysis of single cells using Semi-Permeable Capsules (SPCs). At the press of a button, Flux can process up to 8 samples simultaneously, encapsulating as many as 100,000 single cells into biocompatible SPCs in just 30 minutes. Generated SPCs maintain stability under a wide range of biochemical conditions and are suitable for diverse downstream reactions, which can be performed in a bulk-like manner using standard laboratory equipment.

Onyx is a microfluidic platform designed to generate and manipulate water-in-oil droplets or semi-permeable capsules for high-throughput single-cell and single-molecule analysis. It offers intuitive syringe pump control, high‑speed microscopy, active manipulation, and image-based droplet analysis—all without locking users into specific assays.

This unparalleled flexibility enables effortless integration, customization, and optimization of any droplet-based workflow. Designed for reliability and ease of use, Onyx is the complete solution for laboratories aiming to redefine liquid handling processes with droplet microfluidics.

Styx is a high-throughput screening platform designed to modernize the scientific research, where complex biological parameters are driving the need for advanced functional screening capabilities. It seamlessly integrates multicolor fluorescence analysis, four pressure pumps, and easy-to-use software into an elegant and compact design to bring you the most robust fluorescence-activated droplet sorting (FADS) device on the market.

Styx enables a thousand-fold increase in screening throughput compared to plate-based technologies and allows you to screen millions of functional assays in hours, versus only thousands of functional assays completed by liquid handlers in the same time frame.

Interested to learn more? Let's get in touch!

Mantas Kučinskas Inospectra produktų specialistas

Mantas Kučinskas
Produktų specialistas

  • +370 696 07369
  • mantas@inospectra.com